L-Flox-500

General Information
It is a third generation fluoroquinolone which is optically active levo-isomer or ofloxacin. It has excellent activity against gram-positive, gram-negative, intracellular as well as anaerobic bacteria.

L-Flox-500
Levofloxacin Tablets 500mg

Pharmacologist Index : Antibiotics and Antibacterial Agents.

Pharmaco kinetic:
After oral administration, levofloxacin is near 100% bioavailable. A single 500mg oral or intravenous dose achieves plasma levels that are above MIC levels (against most common pathogens) for 24 hours. It is well distributed to body tissues and fluids, expect that penetration into CNS is poor. It is metabolized in liver. 80-86% of the dose is excreted in urine unchanged with 24 hours and 2% is excreted in faeces.

Indications:
Community acquired pneumonia, complicated urinary infection (incluing pyelonephritis), acute sinusitis, acute exacerbation of chronic bronchitis, skin and soft tissue infections.

Composition:
Each film coated tablet contains:
Levofloxacin hemihydrates
e.q. to Levofloxacin                      500mg.
Excipients                                              q.s.

Method of Action:
All Fluoroquinolones and Quinolones act by inhibiting bacterial DNA gyrase enzyme which is required for DNA replication and thus cause bacterial lysis.

Adverse Effects:
It is well tolerated; most adverse effects are transient in duration and mild to moderate in severity. Nausea, anorexia, abdominal discomfort and diarrhea may be seen after oral administration. After I.V. infusion, phlebitis and reddening at infusion site is reported. Allergic reactions like pruritus, rash, urticaria, bronchospasm, dyspnoea, angioedema.

Contraindications:
Hypersensitivity to levofloxacin or other fluoroquinolones. Epilepsy. History of tendon disorders related to fluoroquinolone treatment. Children and growing adolescents.

Special Precautions:
Severe pneumococcal pneumonia. Nosocomial infections with pseudomonas aeruginosa – consider combination therapy. Pseudomembranous colitis (cease therapy), tendinits. Hypotension. Excessive sunlight.

Pregnancy & Breast Feeding: Contraindicated.

Elderly: May be used.

Interactions:
Anti-neoplastic agents: Serum level of levofloxacin may be decreased. Antacid: Avoid simultaneous use; administer 2-4 hours before or after.

Self Life:
Indicated on the Blister Pack and Carton

Storage Condition:
Store in a cool (between 10OC and 25OC) dry & dark place, Protect from Light.

Presentation:.
10 x 1 x 10 Tablets in Alu-Alu Blister Pack